06/05/2019 / By Evangelyn Rodriguez
In this study, researchers from Korea University in Seoul investigated the hypocholesterolemic activity of hexacosanol on hepatocytes and high-fat–induced obese mice. The results of their study, which elucidate the mechanism behind hexacosanol’s cholesterol-lowering activity, were published in the journal Nutrition Research.
Based on these results, the researchers concluded that the hypocholesterolemic activity of hexacosanol is due to its ability to regulate AMPK activation and suppress SREBP-2, which results in the inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase mRNA expression and protein activity.
Journal Reference:
Lee JH, Jia Y, Thach TT, Han Y, Kim B, Wu C, Kim Y, Seo WD, Lee SJ. HEXACOSANOL REDUCES PLASMA AND HEPATIC CHOLESTEROL BY ACTIVATION OF AMP-ACTIVATED PROTEIN KINASE AND SUPPRESSION OF STEROL REGULATORY ELEMENT-BINDING PROTEIN-2 IN HEPG2 AND C57BL/6J MICE. Nutrition Research. July 2017;43:89–99. DOI: 10.1016/j.nutres.2017.05.013
Tagged Under: alternative medicine, antioxidants, barley, barley sprouts, cholesterol, coronary artery disease, dietary fiber, disease treatments, fatty liver disease, food cures, food is medicine, functional food, heart disease, heart health, hepatic steatosis, hexacosanol, hypocholesterolemia, liver health, natural cures, natural medicine, policosanols, prevention, research
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