Monday, September 17, 2018 by Ellaine Castillo
The risk and incidence of diseases related to bone tissue degeneration tend to increase as people age. According to one study, Resolvin E1 or RvE1, a metabolite of omega-3, can preserve bone tissue.
This study, which was published in Frontiers in Immunology, looked at the role of RvE1 in bone remodeling under inflammation. It had been noted previously that both the immune response and bone interaction are mediated by the ratio between receptor activator of NF-kappa B ligand (RANKL) and osteoprotegerin (OPG).
RANKL is a signal for osteoclastic differentiation, while OPG interferes with the binding of RANKL to its receptor, leading to reduced osteoclastogenesis. Previous studies have shown that when there is inflammation, the RANKL to OPG ratio increases. However, this was only observed in vitro. Building upon these results, the researchers then wanted to show how RvE1 can influence this ratio in vivo.
Results of the study show that RvE1 is able to affect bone remodeling partly because of direct interaction with the bone cells. In the presence of inflammation, it was observed that RvE1 can differentially regulate gene expression and reverse gene expression back to homeostasis levels. In addition to this, the downregulation of signaling pathways that involve inflammatory cytokines, such as NF-kappa B and MAPK, was also observed.
From these results, it can be concluded that RvE1 can preserve bone tissues due to its ability to regulate the RANKL/OPG ratio and the different signaling pathways. This highlights the importance of eating foods rich in omega-3 in maintaining bone health. (Related: Omega-3 fatty acids are superfoods.)
Eating foods rich in omega-3 can help preserve bone tissue and prevent diseases, including osteoarthritis and periodontal disease. Aside from this, there are other ways to support the bones, such as:
Learn more about foods and treatments that can prevent bone deterioration by visiting Cures.news today.